Carolyn W. Gibson, Ph.D. Professor Contact Information Robert Schattner Center University of Pennsylvania School of Dental Medicine Rm 436 Levy Building 240 South 40th Street Philadelphia, PA 19104-6030 Phone: 215-898-6660 Fax: 215-573-3834 Email: gibson@biochem.dental.upenn.edu

Training:

• Rutgers University, B.A. in Biology, 1978
• Temple University School of Medicine, Ph.D. in Microbiology & Immunology, 1982

Research Interests:
Dr. Gibson is Professor of Anatomy & Cell Biology. Her research is focused on the regulation of enamel formation, by studying expression of the genes that encode enamel matrix proteins. She has cloned and characterized several amelogenin genes, and has analyzed alternative splicing of amelogenin RNA. Her lab also studied several families with the enamel defect amelogenesis imperfecta in order to determine the mutations within their amelogenin gene that leads to this condition. She has produced several transgenic mice for studies of expression and function of the amelogenins, including a mouse strain with a null mutation in the amelogenin gene, which has a condition similar to human X-linked amelogenesis imperfecta. Her primary teaching responsibility is as Course Director for Histology and Embryology for first-year dental students.

Selected Publications:

• Gibson, C.W., N.H. Thomson, W.R. Abrams, J. Kirkham. 2005. Nested genes: Biological implications and use of AFM for analysis. Gene 350:15-23.
  
• Li, Y., S. Decker, Z.A. Yuan, P.K. DenBesten,  M.A. Aragon,  K. Jordan-Sciutto, W.R. Abrams, J. Huh, C. McDonald, E. Chen, M.  MacDougall, C.W. Gibson. 2005. Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts. Archs. Oral Biol. 50:681-688.
  
• Prakash, S.K., C.W. Gibson, J.T. Wright, C. Boyd, T. Cormier, R. Sierra, Y. Li, W.R. Abrams, M.A. Aragon, Z.A. Yuan, I.B. Van den Veyver. 2005. Tooth enamel defects in mice with a deletion at the Arhgap6/Amel locus. Calcif. Tissue Int. 77:23-29.
  
• Gibson, C.W., A.B. Kulkarni, J.T. Wright. 2005. The use of animal models to explore amelogenin variants in amelogenesis imperfecta. Cells Tissues Organs 181:196-201.
  
• Li, Y., Z.A. Yuan, M.A. Aragon, A.B. Kulkarni, C.W. Gibson. 2006. Comparison of body weight and gene expression in amelogenin null and wild-type mice. Eur. J. Oral Sci. 114:(Suppl. 1):190-193.

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